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implications for threshold and meaningful change estimation Helen Doll 1 , Michael DeRosa 2 , Shruti Dave 2 , Alyssa Bamer 3 1 Clinical Outcomes Solutions, Folkestone, UK, 2 Clinical Outcomes Solutions, Chicago, Illinois, USA, 3 Clinical Outcomes Solutions, Tucson, Arizona, USA Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :301.5 Aims Receiver operating characteristic (ROC) curve analysis is often used to estimate thresholds related to meaningful change or condition severity

Many major insurance plans now cover semaglutide for weight loss when prescribed for patients who meet medical criteria

Clinical data show that nausea, vomiting, and gastrointestinal upset occur across all GLP-1 classes, but frequency and severity differ by person, formulation, and titration schedule

Psychoneuroendocrinology , 38 (9), 16981708

GLP-1Rs are expressed in the heart, but it is unclear if they have a role in cardioprotection, or if they are primarily involved in the regulation of BP and heart rate (103, 104, 224)