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Therapeutic proteins, monoclonal antibodies, fusion proteins, and pegylated molecules are 200 to 1,000 times larger than small molecules, often comprising tens of thousands of atoms arranged in structures whose clinical activity depends not just on primary amino acid sequence but on higher-order protein folding, glycosylation patterns, charge variants, and aggregation profiles
Some estimates indicate that adults need at least 0.8 grams of protein per kilogram of body weight (0.36 grams per pound) daily
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it does not need to be extreme
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