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This creates a rational decision for IP teams: reduce investment in late-stage secondary patent filings for small-molecule drugs and redirect that IP budget toward earlier-stage patents (where the compound is still within its pre-negotiation window) or toward biologic assets (where the 13-year clock preserves the value of secondary patents in years 9-13)

45 Clinicians should not limit the use of GLP-1 receptor agonists and deny potential medical benefits to patients because of a history of pancreatitis or a likelihood of developing pancreatitis

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Recent clinical evidence reinforces this integrative framework by showing that GLP-1RA and dual incretin agonists modify taste-related behavior through coordinated gastrointestinal, hormonal, and central mechanisms