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In addition to neuron ferroptosis at the lesion site, SCI causes motor cortex atrophy and functional changes early in the disease, and motor neuron death is thought to be the cause of primary motor cortex atrophy after SCI

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It also underscores why replenishing glutathioneeither directly or through precursorsis a primary therapeutic target for neuroinflammation

Future directions include extending support for cohort-level analysis, building three-dimensional (3D) models across serial sections and integrating additional modalities such as spatial epigenomics to further enhance multiomic insight

Setting realistic expectations prevents premature discontinuation