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This typically represents increased activity in healing tissues rather than worsening of the condition

Rules change fast, as seen with semaglutides

In fact, a 2023 paper published in the Journal of Cerebral Blood Flow & Metabolism reported that methylene blue (in similar doses studied by researchers at The University of Texas at Austin who claimed the compound had memory-enhancing properties) led to a 8% decrease in human brain blood flow

But these results are not uniform

It may also support the gut-brain axis by influencing neurochemical pathways and promoting communication between the gastrointestinal tract and central nervous system (CNS)