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According to ClinVar, two pathogenic PRKN variants (p.R275W and p.Q34fs) were found in three PD patients, one PSP patient and three controls (all heterozygous, representing 0.46% of the total cohort, Table 3)
The 5mg/mL option uses twice the water, giving you easier precision at low doses but larger injection volumes at high doses
[1] [5] Rotate injection sites with each weekly dose, avoiding injecting into the same exact spot
Fasting insulin drops 30% to 50% within 8 weeks in most patients (Frias et al., Diabetes Care , 2021)
Reported Side Effects by Dose Level Most gastrointestinal side effects were mild to moderate and occurred primarily during dose escalation
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