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As one of the most abundant intracellular antioxidants, Glutathione participates in numerous biochemical processes associated with cellular protection, metabolic regulation, and oxidative stress response

During hypoglycemia, the counter-regulatory glucagon response remains intact, which adds another layer of safety to the mechanism

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After final alkylation, all samples were diluted (1:1) with 20% ACN/0.1% FA containing 50 nM of deuterated internal standards and analyzed by LC-MS