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The plasma concentrations of homocysteine (17.54.9 vs 12.03.8 mol/l) and also of glycine (19437 vs 14341 mol/l) and glutamine (42251 vs 35351 mol/l) were significantly higher in patients with anorexia nervosa who were not deficient in folic acid, vitamin B 6 and B 12

2024;63:e202407986

The cause affects which treatment works best Medical history: Existing conditions, medications, and allergies that may interact Treatment goals: Whether the patient wants overall brightening, spot reduction, or both This step is what separates a safe, effective outcome from a disappointing or harmful one

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Also consider a folate supplement (680 to 1,360 mcg DFE, or 400 to 800 mcg folic acid), particularly if you're a woman in your childbearing years