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The glucagon receptor activation increases energy expenditure and promotes the breakdown of fat stores, particularly visceral fat that accumulates around organs

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Additionally, these substances depleted ATP levels, impaired mitochondrial function, reduced cell proliferation, and induced autophagy, necrosis, and apoptosis 50

Preclinical Testing: Before human trials can begin, a new drug undergoes laboratory testing and animal studies to assess its safety and biological activity

The first trial that directly compared CagriSema with Mounjaro (REDEFINE 4) found Mounjaro produced more weight loss, and CagriSema didnt meet its main goal of being at least as effective as Mounjaro