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doi: 10.1212/WNL.0000000000008861 164
10.1186/s13578-017-0178-y 124 SwerdlowS
Nat Med 31 , 951962 (2025)
Gln deprivation can enhance the sensitivity of A2780cis cells to cisplatin by promoting the methylation of the GS promoter, inhibiting GS synthesis, and downregulating intracellular GSH levels ( Furthermore, Gln metabolism can also exert epigenetic influences on tumor resistance
For researchers specifically studying inflammatory pathway modulation in soft-tissue and joint models, KPV's inclusion in KLOW provides a third, distinct anti-inflammatory mechanism alongside BPC-157's nitric oxide modulation and TB-500's cytokine-pathway effects
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