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One such hypothesis points the finger at oxidative stress
(PubMed) Wise RA, Holbrook JT, Criner G, et al
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It's the form supported by the largest body of research, it's exceptionally stable in storage, which matters for consistent potency across batches, and it's the form most clinics and pharmacies use as a result
Furthermore, methylation issues can contribute to estrogen dominance , since excess estrogen must be eliminated through our detoxification system
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