The best choice depends on current weight and BMI, weight-related medical conditions, blood sugar status, cardiovascular risk, liver health, kidney function, medication history, side-effect risk, muscle mass and nutrition status, cost and access, patient preference, and long-term maintenance planning
Lancet [Internet] 392(10157):151929
Glucagon Changes liver and fat metabolism and may contribute to greater energy expenditure
See Supplementary table 3A for outcomes in human studies and Supplementary table 3B for outcomes in preclinical studies
The gastrointestinal system contains a high concentration of GLP-1 receptors, which explains why digestive side effects are among the most commonly reported adverse reactions to semaglutide therapy