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None of the seven compounds has completed the large trials required for full drug approval
While Retatrutides primary clinical studies are metabolic in nature, interest from the bodybuilding community reflects curiosity about its broader potential
Semaglutide can also interact with other medications, so its good to know what youre getting into before starting treatment
However, in keeping with our data on receptor pharmacology, increasing the dose to 30 nmol kg 1 , tenfold higher than maximal doses from our studies, shows that tirzepatide does have insulinotropic activity in Glp1r -/- mice or in the presence of a GLP-1R antagonist 5 , demonstrating that tirzepatide can engage the GIPR in mouse beta cells at sufficiently high concentrations
They found an increased risk of DVTs for people taking GLP-1 drugs
