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Mechanisms of disease: endothelial dysfunction in insulin resistance and diabetes
PT-141 shows relatively preserved affinity at MC4R compared to MT-II, making it functionally more MC4R-selective than the parent cyclic peptide
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Downregulation of Endogenous Peptide Production Introducing exogenous peptides may signal the body to decrease its own production of these compounds (a concept well-understood with hormonal therapies)
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