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Safety Considerations As with any compounded sterile injectable, prescribers should screen patients before administration: G6PD deficiency: Patients with known or suspected G6PD deficiency should be evaluated carefully, as IV glutathione and related sulfhydryl compounds have been associated with hemolysis in this population

NADPH helps regenerate glutathione, which creates an important link between these systems

Oral Supplements Oral supplements: Do not require medical staff Can be sold online or in person Fall under DSHEA Carry lower legal risk when labeled and marketed correctly Injectable Products Injectable products: Are drugs under the FDCA Require licensed medical oversight Must come from approved or lawfully compounded sources Carry medical and regulatory risk A center that offers injectable NAD+ or glutathione without meeting these requirements exposes itself to FDA and state enforcement