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Tirzepatide works as a dual agonist, meaning it activates two specific receptors

Study outcomes In this large, population-based retrospective cohort study, our primary outcome was to assess the incidence or new-onset of major adverse cardiovascular events categorized as HF, composite cardiovascular events 23,24 , as well as clinically significant portal hypertension events 25

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The key point is that these interventions work better in the context of reduced mechanical load

The second group included individuals who started and continued either a GLP-1 receptor agonist or SGLT-2 inhibitor for the first time between January 1, 2013, and December 31, 2020