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The rationale for combining them is mechanistic

Patients who are using skin lightening products or undergoing other skin lightening treatments should refrain from exposing themselves as best they can throughout the duration of treatment to avoid risking skin damage, including skin cancer

In the PWA model, GE suppressed hypothalamic expression of BCAP31, a pro-apoptotic protein, and promoted proteins associated with autophagy-critical processes for neuronal function and energy homeostasis

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Not even close to a controlled trial