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These include: A 24-hour liquid-only diet before the procedure (in addition to the standard colonoscopy preparation) Consideration of point-of-care gastric ultrasound to assess for residual gastric contents Anesthesia plan adjustments based on individual risk assessment However, certain higher-risk patients may benefit from temporarily holding their medication

Safety Across the seven PIONEER REAL studies, 1226 adverse events (AEs) in 551 participants (34.1%) were reported during the in-study observation period, and most of these were non-serious (1153 events in 528 participants) and mild or moderate in severity (Table 1)

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81.7% of patients achieved more than 5% weight loss compared to 0% placebo