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After Pycnogenol supplementation for two months, the ophthalmoscopy score significantly improved by 9% in the left eyes and by 17% in the right eyes compared to baseline, whereas there was no change observed in the placebo group
Besides impaired FAO, continuous activation of DNL may also increase PUFA synthesis
The clinical rationale is straightforward: deliver the 5-alpha reductase inhibitor directly to the scalp to reduce local DHT while minimizing systemic absorption and its associated side effects
(2020a)
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