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Despite being mechanistically different, pyroptosis, ferroptosis, apoptosis, necroptosis act synergistically via shared signaling nodes in DKD, with mitochondrial ROS (mtROS) and serving as a pivotal common mediator (30, 112, 176, 207)

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Journal of Physiological Sciences, 2024

When dosing is individualized and carefully titrated, side effects are reduced and long term weight management becomes more achievable

While all are approved for obesity treatment, evidence specifically in post-bariatric populations varies considerably