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Steve Kates, a longtime pharmaceutical executive and expert in peptide design and manufacturing, said one of the chief concerns with some of these peptides is that they have not undergone rigorous, long-term testing typically consistent with FDA-approved medications

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Improved hydration retention : Enhanced moisture-binding leads to visibly plumper, less crepey skin, especially in dehydrated or mature complexions

This was addressed pharmacologically by identifying PAMs, including BPAM and the plant lectin Concanavalin A (ConA), which slowed down desensitization to the timescale of seconds (Gangwar et al., 2024b)