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Low to moderate intensity cardio (walking, cycling, light jogging at conversational pace) performed during the 30-60 minute fasting window maximizes fat oxidation from mobilized fatty acids
This provides substrates for membrane phospholipid peroxidation and makes cells more sensitive to ferroptosis
Moreover, increased expression of G6PD in hepatocytes generates more NADPH for de novo lipogenesis (DNL) which promotes hepatic steatosis and insulin resistance (25, 26)
Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts
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