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The former mainly include sulfonylureas, glinides, dipeptidyl peptidase-IV inhibitors (DPP-4i), and glucagon-like peptide-1 receptor agonists (GLP-1 RA), and the latter mainly include biguanides, thiazolidinediones (TZDs), -glucosidase inhibitors, and sodium-glucose cotransport-2 inhibitors (SGLT-2i)
Only a small proportion (estimated 1-2%) of liraglutide circulates in the free (non-albumin bound) form, ready to diffuse into tissues and bind receptors
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Chronic hyperglycemia contributes to insulin resistance, a metabolic condition in which the body initially fails to respond to the natural endocrine hormone insulin, secreted by the pancreatic -cells
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