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Collagen synthesis in adult skin is slow, elastin almost does not regenerate at all, and as the underlying volume drops, the dermis loses its scaffold and laxity becomes obvious at the jawline, temples, and under-eye region

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GLP-1 is a peptide secreted by L-type enteroendocrine cells in the ileum and colon in response to different nutrients, mainly glucose and lipids, whereas glucose-dependent insulinotropic polypeptide is produced by K cells present in the duodenum and the first portion of the jejunum