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In summary, the reprogramming of hepatocytes associated with a profibrotic milieu results in loss of mature parenchymal cells, characterized by loss of the master hepatocyte transcription factor HNF4 (158, 212) and upregulation of the developmental Notch, Hippo (213), and Hedgehog (214) signaling pathways

Saeki, N., Kuwahara, Y., Sasaki, H., Satoh, H