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Muscle retention requires adequate protein, even when your appetite is reduced

For instance, the study found that women generally saw a higher body mass index (BMI) reduction (12.2%) compared to men (10.0%)

Biochem Biophys Res Commun 83:10931098

We and others previously demonstrated GDF8 and ActA are the two major ligands which mediate the muscle minimization actions of the ActRIIA/B receptors in non-obese mice and NHPs 22,28,30 , and we have further shown that dual blockade of GDF8 and ActA led to much larger increases in muscle mass than blocking either ligand individually, and that dual blockade matched the muscle growth actions of broader ActRIIA/B blockade 28 , similar to effects seen when using a dominant-negative type II receptor or pro-domains of GDF8 and activins 22,26,27

By directly affecting mitochondrial respiration and assisting dopamine receptors and the use of dopamine in the brain