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Excited, Eng tested exendin-4 in diabetic rodents: the results were astonishing exendin-4 lowered blood glucose to normal and kept it low for hours, even over a day in some cases ( [50] )

The only thing new in the current trial compared to the original data set (SURMOUNT-1) is a prolonged look at the safety profile especially, as well as the preservation of the weight-loss and diabetes-prevention effects

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In contrast to this prediction, the same group recently showed that the loss of SLC25A51 enhances nuclear DNA repair, ostensibly because NAD + synthesis is maintained, resulting in higher nuclear and cytosolic concentrations when mitochondrial uptake is blocked 35