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Proven weight loss, the affordable way Up to 15-20% weight loss with Wegovy and Zepbound* Affordable GLP-1s, delivered fast** Covered by top insurance plans Proven weight loss, the affordable way Up to 15-20% weight loss with Wegovy and Zepbound* Affordable GLP-1s, delivered fast** Covered by top insurance plans *In a 68- and 72-week clinical trial studying Wegovy (2.4 mg) and Zepbound (15 mg) in patients without diabetes and with BMI 30, or BMI 27 with a weight-related condition, the average weight loss was 15% and 20% respectively, when paired with diet and exercise changes (compared to 2.4% and 3.1%, respectively, with diet and exercise alone)

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Based on our data, we propose that T3 has a regulatory role in insulin-controlled glucose metabolism, and T3 exerts this function by increasing non-12-OH FXR-antagonistic BA levels via downregulating the expression of CYP8B1, which potentiates GLP-1 production via suppressing the intestinal FXR signaling

& Burcelin, R

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