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The process exhibits a dual role in tumorigenesis by promoting as well as suppressing tumors (167)
Further research is needed to investigate GSH dynamics longitudinally, validate these observations in independent cohorts, explore the therapeutic potential of antioxidant interventions, and confirm these findings in multicenter studies
Upon recognizing and binding lipopolysaccharide (LPS), mouse caspase-11 or human caspase-4/5 proteolytically cleaves GSDMD, leading to plasma membrane rupture (164)
This can appear as mild rashes, itching, or unexpected breakouts
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