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Citation172 For drug discovery, NMR-based fragment screening is often performed in pools wherein multiple-drug fragments are added to one sample and screened for signatures of binding to the protein

Mice with a deficiency of key components in the NF-B pathway die as a result of massive hepatocyte apoptosis induced by TNF 37,38 , supporting the critical role of maintenance of hepatocyte NF-B pathway in protecting against TNF cytotoxicity