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Vitamin B12 deficiency is increasingly recognised as a global public health concern, particularly in developing countries and among high-risk populations

And, when the V max values are set to 10% of their normal values, the number of functional hepatocytes decreases to 10% of normal after 40 hours (the red curve), well below the grey bar marking 30% remaining hepatocytes, which is thought to be the threshold for liver failure[10]

Long-term safety beyond several month treatment courses

If you cant do that, then eventually your thyroid gland will start to damage itself which may result in immune cell infiltration and eventually permanent thyroid gland destruction

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