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SCALE Obesity and Prediabetes: The pivotal trial enrolled 3,731 adults with BMI of 30 or greater (or 27 or greater with comorbidities) without diabetes

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crassa as well as manipulation of inherent biosynthetic genes for precursor amino acids was demonstrated to improve metabolic fluxes toward EGT biosynthesis in the Patent CN116121161, achieving EGT production of 7.1 g/L in 60 h of fed-batch cultivation (Wu et al