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Vitamin B12, also known as cobalamin, is an essential nutrient that plays a crucial role in various bodily functions, including red blood cell formation, neurological health, and energy metabolism

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This inhibition preserves nicotinamide availability for the NAD+ salvage pathway, the primary route for NAD+ regeneration in mammalian cells

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Tyrosine 65 is photolabeled by 8-azidoadenine and 8-azidoadenosine at the NAD binding site of diphtheria toxin