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Notably, many polyphenols also exhibit circadian activity e.g., resveratrol can activate the SIRT1 pathway which influences the clock, and quercetin can modulate clock gene expression in cells
It also activates a group of proteins known as sirtuins, which regulate cell repair, inflammation, and aging
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Within the complex, p53 TAD2 residues 47 to 54 displayed increased rigidity upon binding and consistently maintain an -helical conformation throughout the MD calculations (Fig
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