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The G6PD deficiency is produced by different genetic mechanisms such as deletions, precise mutations and substitutions that affect the transcription, process or primary enzyme structure, which functionally results in a decrease of the enzymatic activity or loss of affinity by the substrate

The antioxidant and anti-inflammatory properties of riboflavin have also been documented in clinical trials

Li GF, Zhao M, Zhao T, Cheng X, Fan M, Zhu LL (2019) Effects of metformin on depressive behavior in chronic stress rats

Meier JJ, Nauck MA, Kranz D, Holst JJ, Deacon CF, Gaeckler D, et al

doi: 10.1080/13543784.2024.2377319 23