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A pre-specified analysis of SELECT trial, showed a clinically relevant reduction in albuminuria with a net treatment benefit of 10.7% (95% CI 13.2, 8.2) in patients with albuminuria at baseline suggesting a beneficial kidney effect of once-weekly subcutaneous semaglutide 2.4 mg in patients with overweight/obesity and established CVD, without diabetes [31]

Meanwhile, GLP 1 receptors in hypothalamic and brainstem nuclei reduce hunger, enhance satiety and shift food preferences away from calorie-dense options

A 2 mg (2,000 mcg) dose is 0.2 mL, which equals 20 units on a U-100 syringe