semaglutide studies in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial Efficacy of Oral Semaglutide: Overview

Prioritize protein and resistance training This does not reduce GI side effects but it directly counters the muscle loss risk, which is the most consequential long-term side effect for body composition

Focus on what you can do, when you can do it, and let consistency build gradually

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Availability of Data and Material Not applicable Ethics Approval Not applicable Consent to Participate Not applicable Consent for Publication Not applicable Author Contributions All authors (F.P, S.M.O, J.M, F.C.S) meet ICMJE authorship criteria, made substantial contributions to the conception and design of the work and to drafting or critically revising the manuscript, approved the final version, and agree to be accountable for all aspects of the work

You lose fat and that can make you look thinner, but also can make you look like youve aged, especially around your face and neck