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The trade-offs: higher cost , supply variability, slower ramp-up, and GI side effects for some patients
The higher doses of Mounjaro (tirzepatide) are more potent compared to the higher doses of Wegovy (semaglutide) which therefore can result in higher percentages of weight loss with Mounjaro
Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (Vinciguerra et al., 2020), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (Vinciguerra et al., 2020
Its very cyclical in nature
