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The FDAs draft guidance on complex drug substances indicates that applicants must demonstrate that their manufacturing process produces a product with the same impurity profile as the reference, not just the same primary sequence
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Serious side effects can occur, including pancreatitis, gallbladder problems, kidney issues, and severe allergic reactions
An emphatic increase in the expression of two markers of mucin levels, MUC2 and MUC5 genes, was observed after metformin treatment (Kyriachenko et al., 2019)
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