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The FDA approved oral semaglutide (Rybelsus) in 2019, and other oral GLP-1 medications like orforglipron are in development
10.1111/j.1541-4337.2006.tb00076.x Comp Rev Food Sci Food Safety
doi:10.1371/journal.pone.0009590 38
Activation of GLP-1R slows gastric emptying, enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon secretion, and produces a robust central satiety signal via vagal afferents and hypothalamic circuits
Functionally, this phase is often marked by a suppression of SCFA-producing genera (e.g., Selenomonadales), potentially depriving the heart of protective metabolites during a critical window of injury 69
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