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To assess the association of semaglutide with incident AUD, the study population included 598,803 patients with T2DM who had active medical encounters for T2DM during 12/20175/2021, were for the first time prescribed semaglutide or non-GLP1-1RA anti-diabetes medications (new-user design) during 12/20175/2021(index event), had no diagnosis of AUD on or before the index event and had a diagnosis of at least one of obesity-associated comorbidities (hypertension, hypercholesterolemia, hyperlipidemia, heart diseases, stroke) on or before the index event
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Zipursky JS et al
The core of the blend is the pharmacological synergy of two independent mechanisms
Their results also provided the first evidence of the molecular weight of glucagon and that it came from a larger precursor (Unger, Eisentraut, Madison
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