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This analysis excluded trials in those with end-stage renal disease, who are at high risk of cardiovascular events and mortality

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No evidence of serious cardiovascular, hepatic, or systemic adverse effects has been observed in available clinical data, distinguishing Melanotan I from less-selective melanocortin agonists

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For best results, Semaglutide GLP-1 is usually introduced at a low dose to minimize any gastrointestinal side effects, with the dose gradually titrated up over several weeks