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For the Met + CC group, both metformin (50 mg/kg) and compound C (2 mg/kg) were injected intraperitoneally daily postoperatively

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At low doses (125 g/kg), metformin activates AMPK, enhancing endothelial nitric oxide synthase (eNOS) activity, improving vascular function, and reducing myocardial injury (Zhou et al., 2001)

Soluble fibre, found in oats, beans, lentils, Brussels sprouts, and flaxseeds, slows digestion and promotes SCFA production by gut bacteria