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Patients were not necessarily fasting, as sampling was done when individuals visited the clinic upon first diagnosis or a returning clinic visit, at which point they were recruited for the study

WH, MC, and RH reviewed the literatures

Sample 1, Sample 2, and Sample 3 are the 100 K concentrates obtained from size cut-off filtration, concentrates from the ion exchange chromatography, and concentrates from the size-exclusion chromatography, respectively