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According to prescribing information and the company's safety disclosures, you should not use GLP-1 medications - or should only do so under specialist supervision - if you have a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, active or recent pancreatitis, severe gastrointestinal disorders that may be worsened by delayed gastric emptying, are pregnant, planning to become pregnant, or breastfeeding, or have severe kidney disease