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Participants treated with liraglutide (239), semaglutide (240), or tirzepatide (200) in the clinical trials had a percent reduction in fat mass approximately three times greater than the reduction in lean mass, leading to an overall improvement in body composition

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The C-terminal domain contributes, together with the N-terminal domain, to shaping the co-substrate binding site, which is termed H-site, from the hydrophobic nature of co-substrates

Additional trials in the TRIUMPH program may address retatrutide effects on cardiovascular outcomes, sleep apnea resolution, and kidney function, though these have not yet been formally announced