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The Biological Basis for MOTS-c and 5-Amino-1MQ Synergy MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA that functions as a metabolic regulator by activating AMPK (AMP-activated protein kinase)the enzyme that shifts cellular metabolism from anabolic (energy storage) to catabolic (energy utilisation)

In addition, an antifibrotic activity in fibroblasts and adipocytes from GO patient has been reported, and quercetin seems also to be able to reduce the adipogenesis induced by cigarette smoke-extract in GO fibroblasts

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