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The scaffold is a 23-membered macrocycle closed by a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, with norleucine at position 4 in place of the oxidation-prone methionine of the native hormone and D-phenylalanine at position 7 inside the conserved His-Phe-Arg-Trp message core
It mimics GLP-1, a hormone that regulates appetite and blood sugar levels
I was a little nervous about increasing the dose, but Ive had almost no side effectsmaybe just a little fatigue here and there when I havent eaten enough, but nothing major
This reduced rate of death in culture resulted in extended survival (up to 40 days) of rat sensory neurons in primary culture [15]
Emphasize SEM and GLOO
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