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Both work completely differently

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At much higher concentrations, melatonin may act as an electron donor, promoting a receptor free non-specific antioxidant response ( Melatonin receptors MT1 and MT2 couple to Gi/o and beta-arrestins and depending on the context also couple to Gq ( Pineal melatonin exerts a wide range of physiological actions due to its release into the cerebrospinal fluid (CSF) and bloodstream

Those with certain health conditions, like liver or kidney issues, should consult a healthcare provider before starting treatment