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Tirzepatide's clinical evidence: The SURMOUNT-1 trial, published in the New England Journal of Medicine (2022), enrolled 2,539 adults with obesity who had at least one weight-related comorbidity excluding diabetes - a population chosen to test tirzepatide's weight management efficacy in a cleanly obesity-focused cohort rather than a diabetes-management context

Disposable needles will need to be put into a puncture-proof metal or hard plastic container, often called a sharps container. Injection using a disposable needle/syringe As with prefilled injection devices, consult with your healthcare provider about medication dosing and delivery

They may just adjust their activity level to compensate

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Planned taper versus another eligible strategy